Tholi Prema is a romantic love story with family sentiment in whihc, Balu (kalyan) is the youngest son in the family, and is also a careless guy. He falls for Anu(keerthi), who returns from USA to spend time with her grand father. Anu is impressed with balu, when he saves a kid's life and tries to get his autograph, but fails. Balu leaves for Ooty for his studies, but accidentally meets Anu on the way, when his taxi is broken. Anu's car slips into a valley, and trying to save anu, balu slips off too. Anu is depressed that balu sacrificed himself to save her, searches for him but loses hope. Balu is saved by a truck driver and admitted in a hospital. On his return, anu meets balu at his house to express her gratitude. Balu thinks of proposing his love, but is warned by his sister(vasuki). Balu develops friendship with Anu, but never dares to express his love. Vasuki gets married and leaves, and at the same time anu too gets admission in USA and is about to leave. Rest of the story is about how these two express thier love with each other.