Simhadri is an Action based movie. In which, Simhadri(NTR) is handpicked by Ram Bhupal Varma(Nazar). The bond Ram Bhupal Varma and Simhadri share is like that of a father and son. Kasturi (Ankita) is the grand daughter (daughter's daughter) of Ram Bhupal Varma. Kasturi likes Simhadri a lot. Once in a week, Simhadri visits a mentally retorted girl called Indu (Bhumika).
Mean while a bunch of gangsters are in search of Simhadri. They found him at the banks of Godari River along with Indu. In that confrontation between gangsters and Simhadri, Indu gets injured. When she comes back to her senses, she becomes a normal girl. The first thing she does then was to stab Simhadri.
Simhadri is hospitalized. Then we see hoards of buses coming from Kerala to see Simhadri, whom they call as Singamalai. In the flashback it is revealed that Ram Bhupal Varma's elder daughter Seeta (Seeta) elopes with a guy (Bhanu Chandar). They settle in Kerala. Simhadri takes up the job of uniting family and visits Trivendrum. There he finds Indu as the grand daughter of Ram Bhupal Varma.
He convinces the separated family and when the reunion is about to happen, Seeta is stabbed by a local goon Nair (Rahul Dev). A rowdy named Bhai Saab (Mukesh Rushi) controls the mafia of Kerala. Nair and Bhai Saab belong to the same mafia. Simhadri takes law into his hands and eradicates goons in Kerala