Sheshadri Nayudu is an Action Sentiment oriented movie In which, Seshadri Naidu (Srihari) is an orphan who grows up by taking care of his blind younger sister. He runs a hotel in city which serves a meal for just one rupee. He sells meals for one rupee so that each and every poor man can afford it.
CM of AP is an honest guy. There are four corrupt MLAs who want to get rid of the CM, because they were denied MLA tickets in the next assembly elections. In a bid to strip the CM off his post, they bomb a gathering at Seshadri's hotel. Seshadri chases the culprits and proves that these four MLAs are criminals. Sitting behind the bars, they hatch a plan to seek revenge on Seshadri.
Seshadri's blind sister falls in love with one of the MLA's sons. Seshadri marries them off after realizing the noble intentions of that guy. Later on, she is deceived by her man and she kills herself. The rest of the story is all about how Seshadri took revenge on the son of the MLA.