Sathyame Sivam is an Comedy Darma based movie. In which, Satyam (Madhavan) is a savvy ad filmmaker who is stuck in Bhuvaneswar airport due to natural calamity. Sivam (Kamal Hassan) is a nerd-like handicapped man who is very raw. These two people with contrasting personalities meet each and become friends forcibly due to the situation they are thrown in.
Satyam is in hurry because his marriage is about to happen in 4 days. All the communication systems and commuting facilities are dislocated. Satyam and Sivam embark on their journey back to Hyderabad through various modes commuting. In their journey they encounter so many things. Satyam learns that Sivam is a wonderful human being.