Sainikudu Film starts with floods at Rangasaipet in Warangal District. Houses, trains and people inundate in flood water and Siddarth, (Mahesh Babu) a young man saves the people up to his maximum effort. Eight of his friends assist him in the rescue activity.On the other hand Chief Minister (Kota Srinivasa Rao) recommends the candidature of Pappu Yadav (Irfan Khan), for Assembly Elections. Pappu Yadav is a goonda who wishes to earn big through politics and power. To get the attention of people Pappu Yadav announces a sum of Rs.5 Crore for flood victims.
The food that needs to reach the victims of the flood is taken elsewhere to be sold out, an illegal way of earning money by selling the food and as well backing up the flood relief fund into the pockets of the politicians. Siddharth gets to know this through one of his friend and saves the stock in time and take it to the flood victims for distribution.This annoys Pappu Yadav for which Mondi Nani (Prakash Raj), Pappu's right hand, threatens Siddarth. A strife develops between Mondi Nani and Siddarth and the latter declares that his friend (Ajay) would be contesting in the next Assembly Election opposite Pappu Yadav. Siddarth and his team get accolades from the people for this decision and thus start campaigning. To cut the good-name of the group in the people and to win sympathy , Pappu Yadav conspires for a bomb blast allegation on Siddarth and Co. Mondi Nani works for him and the mission accomplishes.
Pappu Yadav declares Siddarth and Co as terrorists and wins the election. Pappu Yadav becomes the Home Minister and his marriage settles with Vara Lakshmi (Trisha Krishnan). Siddarth, with the help of many college students kidnaps Varalakshmi from marriage hall in a dramatic sequence, demanding Pappu Yadav to let out his crimes before the court of law.Rest of the film shows Home Minister Pappu Yadav chasing Siddarth for getting his bride Varalakshmi back. ACP (Telangana Shakuntala) also assists him and spills a little comedy with her style of dialogues. The film has no twists and turns and major part goes with chasing aspect.Finally, how Siddarth puts an end to the game of crooked politicians has to be seen on screen.