Kushi Kushiga is a remake of Malayalam blockbuster 'Chronic Bachelor' which was later become a blockbuster 'Engal Anna' in Tamil. The story of the movie all about Surya Prakash (Jagapati Babu) who is a chronic bachelor. He hates love and girls. He has a nemesis called Bhavani (Ramya Krishna). He wins a court case against Bhavani that entitles him of a fortune left by his deceased father. Bhavani vows to see the end of Surya Prakash.
Surya Prakash's residence is adjacent to a Girls Hostel. Surya Prakash secretly sponsors a girl called Sandhya (Nikita), who is a step sister of Surya Prakash. But Sandhya is unaware of this fact. Sree Kumar (Venu), who is a brother-in-law of Surya Prakash, is a Casanova. He falls in love with Sandhya at the very first sight. Satya Bhama (Sangeeta) is also an inmate in the Girls Hostel. She falls in love with Surya Prakash. Later it is revealed that Satya Bhama is a younger sister of Bhavani.
The rest of the story deals with how all these relationships fall in place and lead to a logical conclusion.