Jayam Manade Raa is action based movie in which, Abhiram(Venky) is a fun loving guy staying with his parents in Europe. A bunch of 10 people won the contest of Thumps up, which gave them an opportunity to tour Europe. Uma (Soundarya) is one of the contest winners. Abiram likes Uma and acts as a tour companion for them during their stay in Europe. A shy Uma could not express her love towards him so she leaves a message in Abhiram's answering machine. But Abhiram could not listen to the message at the right time. Hence, Uma presumes that Abhiram does not love her and leaves back to India with her companions.
Abhiram, who happened to listen the message after Uma left, calls up Uma and make a contact with her. But it's too late for him, as the father of Soundarya (Prasad Babu) commits a marriage for her daughter with Purushottam (Surya), the son of main villain (Jaya Prakash).
On the other track, a parallel story is running in which Jaya Prakash and his gang of goons is searching for 'Rudrama Naidu'. When the father of Prasad Babu sees the photograph of Abhiram, he gets frieghtened and approach Jaya Prakash with the photograph. Jaya Prakash wants to eliminate 'Abhiram'. rest of the story is why JayaprakashReddy wants to kill Abhiram.