Gayam is a remake version of tamil movie Pattiyal and the story revolves around two friends Arya and Bharath who are contract killers working for a middleman with the ironic Cochin Haneefa.
Arya who is an unblinking man with nary a feeling for life. Bharath who is a deaf and dumb and is equally intrepid.
Padmapriya who is a salesgirl at a garment company is an outgoing and sprightly girl and is a friend of both Arya and Bharath. She is in deeply in love with Arya. however, has no time for such finer emotions.But Cupid strikes his comrade-in-crime Bharath who takes a liking to Pooja, who is a salesgirl in a medical shop.
Life takes a decisive turn when the duo are sent on a mission to bump off a businessman and politician Santhanabharathy. By now the killers are a bit tired of their wicked ways.
They decide that after this final assignment, they would give up crime and lead a new life. But the plot takes many a twist and turn.