Four Friends is a dubbed version of Malayalam movie Four Friends. In which, Roy (Jayaram), Surya (Kunchacko Boban), Amir (Jayasurya) and Gowri (Meera Jasmine) join a cancer institute called Pratheeksha run by Dr Nandakumar (Ganesh) as patients to undergo treatment.
However, they don’t want to depress instead try to find ways to live their remaining life happily. In the process, all the four become thick friends. Soon, they decide to visit places of interest among them and select Malaysia where Surya’s girlfriend lives. In fact, it is the words of Kamal Hassan that inspire them from falling into depression. in which Kamal Hassan has done cameo.