Amma Nanna O Tamila Ammayi is an Family Darama based movie. In which, Chandu is a kickboxing student and aspires to become the champion. He has a caring mother (Jayasudha) and no father. His father leaves them long back to achieve his goal, as he felt that his family is becoming hindrance to his career growth. Chandu loses his mother in due time. His mother asks him to go to Vizag and stay with his father Raghuveer (Prakash Raj) for the rest of his life.
Chandu travels to Vizag and finds that Raghuveer married another lady called Shalini (Aishwarya) and they have a daughter as well. Raghuveer is a kickboxing coach. He invites Chandu with both hands. But his wife and daughter are not comfortable with Chandu.
The rest of the story is about how Chandu wins the love of all family members and also the kickboxing Championship.