Akasa Veedhilo is a family oriented movie in which, Chandu (Nagarjuna) and Suri (Rajendra Prasad) are pilots. They are thick friends. Indu (Raveena Tandon) and Padma (Kasturi) are very good friends.
Chandu gets married to Indu and Suri marries Padma. Indu and Padma become pregnant. Indu meets with a car accident and she becomes ineligible to become a mother. Padma gives birth to twins, Ram and Lakshman.
Indu and Chandu adapt Ram. After three years, bone-marrow cancer infects Lakshman. He needs to be operated with bone marrow transplantation. When Chandu asks the permission of Indu to use Ram's bone marrow for Lakshman's opion as they are twins, Indu refuses and flees to Delhi fearing that Chandu will force her to send Ram for operation.
rest of the story is about how they save Lakshman from that infects.