Ninaithale Inikkum story is about a group of college friends and problems faced by them. Shakthi with his golden voice is the doyen of the college campus. Prithviraj is a firebrand student leader with leanings towards the left. Karthik Kumar leads the opposite faction. Priyamani is the daughter of the local MLA and a danseuse who wins numerous awards for the college with her performance. Bhagyaraj is the lecturer.
It was Shakthi s dream that these classmates should have a reunion ten years from graduation. But Shakthi dies under mysterious circumstances. His parents who both teach at the college decide to fulfill their departed son's dream and bring his classmates together for a reunion. The coming together of these classmates is an occasion for the participants to regurgitate the past and go nostalgic also reveals the truth of Shakthi death mystery.