Meera movie revolves around Meera ,a rich girl. The movie starts off with a pregnant Meera in a college nearing labour. Here Meera tells her story of how she got to this point (flashback). A young man named Jeeva falls in love with her but she despises him and she eventually gets him kicked out of college after certain circumstances.
After a fight with Jeeva near her house, Meera goes out for a walk and she sees a woman getting killed by a police man. She is terrified and runs to the police station to report the crime and the officer at the station is shockingly the murderer. The police officer now knowing the sole witness to his crime sends goons to her house to kill her. By then Meera has already left and is on the run. Jeeva goes to Meera's house and finds the maid getting beaten by the goons. A fight between Jeeva and the goons occurs. Jeeva wins and the maid tells him he should go after Meera. They are now on the run and the murderer sends 6 professional killers after the duo.
Along the way Meera and Jeeva get arrested by comedic policemen and later flee. They find a blacksmith and freed of the handcuffs but are almost killed but the goons in the shootout. Meera leaves Jeeva but has a change of heart and comes back. She finds the goons who have Jeeva and the goons tie Jeeva and Meera together on train tracks but the narrowly escape. After this event Meera admits her love for Jeeva. After a run in with the murderer, Meera and Jeeva end up in the ocean and wash up near the house of a boy named Jesu and his grandfather. The seek refuge there and Meera gets close with Jesu.
While everyone is getting ready for Jesu`s birthday, Jesu dog runs off into the forest. The goons kill the dog and are after Meera. Meera and Jesu flee on Jesu bike but the both fall off the bike and Jesu gets killed. Jeeva takes revenge and kills the goons in gruesome ways. A final showdown occurs between the Murderer Officer and Jeeva. The officer gets the upperhand and almost succeeds but Meera shoots him and Jeeva sets him on fire. The final scene is a group photo with everyone and Meera goes into labour.