Kokki movie is all about Kokkisamy (Karan) who is a taciturn villager comes to Chennai. His foster father Subburaj (Malaysia Vasudean) who runs a salon takes care of Kokki. He helps get Kokki a job abroad. He comes across a local bigwig Upilliappan (Kotta Srinivasa Rao) who is a strong believer in astrology.
One day Kokki comes to Uppili's house to hair dress one of his men. That day, Uppili wakes up and sees Kokki instead of the statue. Everything that he does that day works in his favor. The superstitious Uppili now wants to have Kokki around as a harbinger of good luck. But Kokki refuses and his life was not the same from there on.
Uppili implicates Kokki in a false case and brands him as criminal. With a criminal record his dreams to go abroad collapse. Kokki manages to escape from jail and is on the run.
He hides in a ladies hostel where he meets Raji (Pooja Ganghi), who decides to help him after hearing his story. The remaining story is all about Kokki escapes from prison and how he avenges Uppili.