"I'm here tonight to honour my heroes and luckily I have many to look up to - and many to look at tonight. We want nothing less than every other American," femalefirst.co.uk quoted Gaga as saying.
"We are not a niche, we are part - a big giant part - of humanity. We are the continuum. We are ongoing. We continue the spirit of the first official Gay rally in 1970 in New York, one year after Stonewall," she said.
"And although this weekend is a time for victory, I am a citizen of New York and I demand the right to safe streets; the violence that has taken place against LGBTs is unacceptable, here and anywhere. Enough is enough," she added.
Gaga also said that her past experiences of being bullied had made her all the more determined to set an example to struggling teens. "I wasn't naturally thin like most of my female classmates. My Italian heritage showed its stronghold in my nose and I found it very, very hard during this time to maintain any healthy friendships and healthy sense of self," she said.
"I'm here for the youth and to be a visible figure for them, to help them become the best individuals they can, with no limits on their potential, their future," she added.