Vamanapuram Bus Route movie is all about Lever Johnny (Mohanlal) who is a bus conductor. e beats up everything and anybody who comes in his way and showers abuses at everybody. This drama every night disturbs the Vamanapuram village. The trouble of Lever Johny started with the railway gate that separates the village from other regions always lying closed and the road is not tarred due to which the bus does not come to the village. The village is filled with idiots (Vamanans) and their chief is Gopalan Nair.
Panchayat president Gopalan Nair, a man famous for his wickedness wants to start a bus service in his village. The opposition party in the village panchayat is against this idea, as they suspect Nair's intentions. But he goes forward with the idea. Gangadharan the biggest bus owner who operates buses even during bandh day sends his bus Padakkuthira to Vamanapuram but it returns without entering the village due to Nair's scheming idea.
This incident anger Gangadharan and he sends his favourite bus conductor and cleaner Lever Johny to Vamanapuram with his bus. From that day onwards the residents of Vamanapuram spent sleepless nights. Though Johny turns violent after drinking in the night he does not remember anything the next day morning. In the daytime he wears dresses which MGR and imagines himself to be MGR.