Rhytham movie tells the story of a bunch of friends and their relationships. Aryan, Dileep, Nirmal and Priya (Shanavas, Adithyan, Prashanth and Anjali) who are orphans brought up under the loving care of Father Gabriel. All four are blind by birth, but want to lead their lives without depending on anybody. So they decide to earn their own living, and take a house on rent and start working.
Aryan and Nirmal work in a music store, while Priya works in a shop selling flowers. Dileep gets work in a tea manufacturing unit. Their lives begin to change and they start living like ordinary human beings, almost forgetting their physical disability.
It is then that things start taking a new turn for them. Priya finds place in the minds and thoughts of Aryan and Dileep, both of whom fall in love with her. They vie with one another for her attention, and even work out plans to outwit each other.
In the meantime Dileep gets his eyesight and that gives a new twist to things. What follows forms the rest of the plot.