Nirnnayam movie is about wrongly convicted of murdering his wife, Dr. Roy(Mohanlal) who escapes from a prison bus and tries to find out why she was killed and who the murderer really was. He is relentlessly pursued by a commissionar M. Javed Khan (Lalu Alex) and is forced to keep out of contact from any friends or relatives. However, his determination and ingenuity soon produce results and he comes to the frightening realisation that he can trust no one.
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