Meesa Madhavan movie is about Madhavan (Dileep) who is better known in the village as ‘Kallan’ Madhavan as he is a petty thief. Strangely everybody in the village adores him, as he is a sort of Robinhood to the villagers. Madhavan had a childhood friend Rugmini (Kavya Madhavan) who later went to the city for studying in a city college. Her father Bhageerathan Pillai (Jagathy Sreekumar) is a local landlord and moneylender.
Pillai hates Madhavan and when his daughter comes back from city, he brainwashes her against Madhavan. So, Rugmini too hates him and sees that she traps Madhavan by hook or crook. But later she realizes that Madhavan has a heart of gold and starts loving him. As the love blossoms between them, sub inspector Eapen Pappachen (Indrajeet) comes to the village and soon has a confrontation with Madhavan. Along with Pillai, Eapen spins a web for Madhavan and accuses him of stealing the idol from the local temple.
How the lovers unite in the end forms the climax of the movie