Mayookham movie revolves around Unni Kesavan (Saiju) and Indira (Mamta) who are childhood friends. Indira goes to US with her father (Saikumar) who is a doctor and comes back after many years to their family house. She meets Unni and is shocked to see him as a rebel. She tries to help him by supporting and giving him a new lease of life and slowly love blossoms between the two.
Indira become the light in Unni’s life and she motivates him to turn responsible. But fate plays dirty as Indira is terminally ill and she goes back for treatment.