Malayalimamanu Vanakkam movie tells Anandakuttan's mother (Srividya) wants her daughter Anandavalli(Shobha Mohan) to be with the family for Anandakuttan's (Jayaram) marriage with Revathy (Suja Karthika). So he is on his way to Tamilnadu in search of his sister and her husband Muniyandi (Kalabhavan Mani).
But Muniyandi wants to take his revenge against Anandakuttan's father who had cut one his legs. Anandakuttan finds out his sister and she sends her daughter Parvathy (Roja) with Anandakuttan home. Parvathy starts falling in love with Anandakuttan. In the mean time Muniyandi, who is Thiruppathy Perumal now.