Madhya Venal movie revolves round Sarojini (Swetha Menon) who is a house wife ans who is a social worker too. Majority of the villagers depend on the Khadi weaving mills for their livelihood. Sarojini too runs a mill. Her husband Kumaran (Manoj K jayan) who is a political worker. During that period Praveen (Arun) who is an executive from a new generation bank comes to help the villagers. Without any proper documents he lends money to them. Being innocent they do not realize the trick behind Praveen's business.
Sarojini and Kumaran try their level best to make the people understand Praveen's intention. Meanwhile Praveen fakes love for Manikutty, the daughter of Kumaran and Sarojini, since they were against him. The sufferings and sacrifices a woman has to face in the society is brought out very beautifully in the movie.