Highway Police revolves around Two young men Mammad (Babu Antony) and Circle Inspector Jayachandran (Riyaz Khan) are forced to swallow their anger at not being able to hunt down their fathers’ killers.The cop’s father was an scrupulously honest customs officer, who was killed by smugglers. Jayachandran joins the police force to track down his father’s killers.
Khan Bhai, an underworld don who is behind the nefarious activities in Cochin, was responsible for the two murders. The Bhai mainly uses the highways for his illegal activities. CI Jayachandran is assigned the task of patrolling these highways. He sees his new posting as a golden opportunity to hunt down his father’s killers.
A club dancer Ranjini (Indraja) helps in their mission because her husband, Danny (Prakash Paul) too was murdered by Bhai’s goons. ctually Danny used to work for the don and Rajini, who belongs to a well-to-do family, falls in love with him without checking his background. After their marriage, Khan Bhai forces Rajini to dance in his club, when the couple refuse to relent, Danny is bumped off.
Mammad rescues the distressed widow from Khan Bhai’s clutches and gives her shelter. In the climax Khan Bhai’s evil empire crumbles under their combined might.