Moggina Manasu in this movie Renuka Devi (Shubha Punj) and Chanchala (Radhika Pandit), after passing 10th standard, join Queen's college for their pre-university study. The girls face a ragging session conducted by two senior students Sanjana (Sangeetha Shetty) and Deeksha (Manasi). After the ragging, the girls become enemies, but later, become close and inseparable friends.
The story takes a twist from here, as the girls start having affairs. Renuka Devi is heartbroken and commits suicide, while Chanchala withdraws from her relationship with a popular singer Rahul to prosper in her studies. Rahul is dejected but in the end, gets back to Chanchala. The parents of the girls are the ones who go through hell all the while the girls are having fun with their lives.