Kamannana Makkalu story revolves around three thieves Kaamanna and his two adopted sons-Krishna and Rama. All of them decide to reform and prepare for a new lease of life. Accidentally they are made to stay in a village where the people are terrorized by the goons of the village head.
Rama and Krishna drive out the goons who attack the house of Shivaramaiah, a poor man in the village. Krishna falls for the daughter of Shivaramaiah. Later circumstances lead to Rama tying the nuptial knot to Village head's daughter. Finally Rama and Krishna are united with their lady loves after both of them expose the villains.