Harold & Kumar Escape from Guantanamo Bay film is sequel to the 2004 film Harold & Kumar Go to White Castle. New Jersey-based Harold Cho and Kumar Patel decide to travel to Amsterdam so that Harold can be near his sweetheart, Maria.
At the airport, the duo meet with Kumar's ex-girlfriend, Vanessa, in the company of her fiancé, the highly connected, Colton. After an encounter with security personnel, both board the plane, and are soon apprehended by two of the three air marshals as Kumar was smoking pot using a home-made contraption. The plane is forced to return back and both are taken into custody by the Homeland Security.
Here they are found mistakenly guilty of being terrorists and transported to Guantanamo Bay in Cuba. Barely an hour later both manage to escape, join hands with Cuban refugees and land back in the U.S.. They attend party hosted by their friend, Raza Syed who lends them his convertible. They decide to travel to Texas, meet with Colton, who will use his connections to set matters right. After an eventful journey they finally manage to reach Colton's place, and he, in turn, promises to take care of them.