ALMA Awards 2000 - ALMA Award - Outstanding Actress in a Feature Film for Any Given Sunday (1999)
1998 - ALMA Award - Outstanding Individual Performance in a Crossover Role in a Feature Film for My Best Friend's Wedding (1997)
American Comedy Awards, USA 1999 - American Comedy Award - Funniest Actress in a Motion Picture (Leading Role) for There's Something About Mary (1998)
Blockbuster Entertainment Awards 2001 Blockbuster Entertainment Award - Favorite Action Team (Internet Only) for Charlie's Angels (2000) Shared with Drew Barrymore, Lucy Liu
2000 - Blockbuster Entertainment Award - Favorite Actress - Drama for Any Given Sunday (1999)
1999 - Blockbuster Entertainment Award - Favorite Actress - Comedy for There's Something About Mary (1998)
1998 - Blockbuster Entertainment Award - Favorite Supporting Actress - Comedy for My Best Friend's Wedding (1997)
Boston Society of Film Critics Awards 2001 - BSFC Award - Best Supporting Actress for Vanilla Sky (2001)
Chicago Film Critics Association Awards 2002 - CFCA Award - Best Supporting Actress for Vanilla Sky (2001)
Imagen Foundation Awards 2004 - Imagen Award - Best Actress in a Film for Charlie's Angels: Full Throttle (2003)
Kids' Choice Awards, USA 2008 - Wannabe Award
MTV Movie Awards 2001 - MTV Movie Award - Best Dance Sequence for Charlie's Angels (2000) For her fantasy sequence.
2001 - MTV Movie Award - Best On-Screen Team for Charlie's Angels (2000) Shared with Drew Barrymore, Lucy Liu
1999 - MTV Movie Award - Best Female Performance for There's Something About Mary (1998)
New York Film Critics Circle Awards 1998 - NYFCC Award - Best Actress for There's Something About Mary (1998)
People's Choice Awards, USA 2007 - People's Choice Award - Favorite Leading Lady
ShoWest Convention, USA 1996 - ShoWest Award - Female Star of Tomorrow
Teen Choice Awards 1999 - Teen Choice Award - Film - Most Disgusting Scene for There's Something About Mary (1998) Mary discovers a great new all-natural hair gel.