U, Bomsi n Me is a story of Raghavan or Rags who is intelligent though laid back and just wants to be himself. He is clumsy, loves watching cricket and drinking his beer married to Raji, a statistics lecturer who hates cricket and is obsessive about cleanliness. Bomsi (a Parsee) is an aggressive, chain smoking salesman who wants to be very rich and buy a house in a Parsee colony. He is married to Shenaz, also a salesperson who wants to have a baby. But they are not able to conceive.
'Me' is Sam MacPatel (half Gujju-half Punju), a creative person who wants to be a writer and a famous one at that. He is married to Monica (a Goan) - an air hostess and hence always traveling; she is in love with the idea of being in love. When they are together, Sam wants to go out while Monica wants to cuddle up with Sam and watch mushy movies. Because of long days of separation, they sometimes suspect each other of infidelity.
The trio work in an FM radio station as Operations, Sales and Programming heads respectively and are in their first three years of marriage, trying their best to deal with the conflicts in their married lives and their professional pressures. With a short, pot-bellied, bald, bachelor boss who seems to have all the fun dating tall girls & driving fancy cars, life just doesn't seem fair. U, Bomsi n Me is a cosmopolitan hinglish musical romantic comedy about these three DINKs (Double Income No Kids) couples who resolve their conflicts by exploring romance within marriage.